Welcome to the Glass Lab
Our lab is interested in cell specialization, communication and nonself recognition, all crucial mechanisms in microbial organisms such as filamentous fungi.
Publications
Huberman LB, Villalobos-Escobedo JM, Skerker JM, Shi R, Rico-Ramírez AM, Adams C, Arkin AP, Deutschbauer AM, Glass NL, 2025. Construction of a randomly barcoded insertional mutant library in the filamentous fungus Trichoderma atroviride. bioRxiv 11.30.691285. doi: 10.1101/2025.11.30.691285.
Huberman LB, Wu VW, Kowbel DJ, Lee J, Daum C, Singan VR, Grigoriev IV, O’Malley RC, Glass NL, 2025. A novel regulator of the fungal phosphate starvation response revealed by transcriptional profiling and DNA affinity purification sequencing. mBio16(10):e0202325. doi: 10.1128/mbio.02023-25
Alder-Rangel A, Rangel AEA, Casadevall A, Gusa A, Xue C, Boone CM, Hittinger CT, Masuda CA, Olivares-Yañez C, Bell-Pedersen D, Washington EJ, Braus G, Janbon G, Pócsi I, Stajich JE, Dunlap JC, Bennett JW, Heitman J, Lu L, Landi L, Shinohara ML, Del Poeta M, Acheampong MA, Maltz MR, Lorenz MC, Nowrousian M, Glass NL, Broderick NA, Pedrini N, Osherov N, Billmyre RB, Sarrocco S, LeibundGut-Landmann S, Vicente VA, Lin X, Zhao XQ, Bahn YS, Lewis ZA, Rangel DEN, 2025. Celebrating the fifth edition of the International Symposium on Fungal Stress – ISFUS, a decade after its 2014 debut. Fungal Biol. 129(5):101590. doi: 10.1016/j.funbio.2025.101590.
Rico-Ramirez AM, Glass NL, 2025. Identification of regions required for allelic specificity at the cell wall remodeling checkpoint in Neurospora crassa. Genetics 230(2):iyaf062. doi: 10.1093/genetics/iyaf062.
Stark FG, Torii-Karch M, Yuvaraj S, Bonometti L, Gladieux P, Glass NL, Krasileva K, 2025. Molecular insights into fungal innate immunity using the Neurospora crassa-Pseudomonas syringae model. bioRxiv 01.22.633611. doi: 10.1101/2025.01.22.633611.
News
Louise Glass, together with Barbara Baker and David Card, Faculty members of UC Berkeley, have been elected to join the... Read More
A recent article in the Proceedings of the National Academy of Sciences (http://www.pnas.org/content/117/11/6003.long) reports on how a fungus senses and... Read More
Focalization of Lifeact-GFP (actin marker) upon cell contact (arrow) in germlings of Neurospora crassa. Image of live cells was acquired... Read More
Darae presented her doctoral thesis work entitled: Dissecting the mechanism of signaling and regulation of chemotropic interactions during cell fusion... Read More
From left to right: Linfang, Louise, Gabe, Lori, Jens.... Read More
Glass Lab
We’re based in the Department of Plant & Microbial Biology at the University of California, Berkeley. Our lab is interested in cell specialization, communication and nonself recognition, all crucial mechanisms in microbial organisms such as filamentous fungi.
Some of our research interests are focused on understanding the signaling mechanisms that mediate cell fusion and the nonself recognition mechanisms that occur before and after fusion. The experimental tractability and availability of a large number of mutants in the filamentous fungus Neurospora crassa makes it a superb system to delineate both fungal-specific and general mechanisms of cell communication and nonself recognition.
We use a combination of molecular biology, genetics, cell biology, genomics and bioinformatics to investigate these subjects. Recently we have begun to study how plant cell wall degradation is orchestrated by fungi, and how fungal enzymes are secreted. Our long term goal for this project is to significantly improve the efficiency of plant biomass degradation by fungi. Neurospora crassa is a model cellulolytic fungus, thus we are also using this species for these studies.